Yogulitsa Yogulitsa Kugulitsa Ibrutinib Intermediates N-3 CAS 330792-70-6

Poganizira mawuwa, tsopano takhala m'gulu la opanga mwaukadaulo, otsika mtengo, komanso opikisana pamitengo ya Wholesale Hot Selling Ibrutinib Intermediates N-3 CAS 330792-70-6, Tikuyembekezera kukupatsirani zinthu zathu posachedwa, ndipo mupeza kuti mawu athu ndi omveka bwino komanso mtundu wazinthu zathu ndizabwino kwambiri!
Poganizira mawuwa, tsopano takhala m'gulu la opanga luso laukadaulo, otsika mtengo, komanso opikisana pamitengo.China Ibrutinib N-3 ndi Intermediates, Pakalipano malonda athu atumizidwa kum'mawa kwa Ulaya, Middle East, Southeast, Africa ndi South America etc. Tili ndi malonda a 13years akatswiri ogulitsa ndi kugula m'magawo a Isuzu kunyumba ndi kunja komanso umwini wa makina amakono a Isuzu apakompyuta.Timalemekeza mkulu wathu wamkulu wa Kuonamtima mubizinesi, kukhala patsogolo pautumiki ndipo tichita zonse zomwe tingathe kuti tipatse makasitomala athu zinthu zapamwamba kwambiri komanso ntchito yabwino kwambiri.

Pakatikati pa kaphatikizidwe ka allopurinol.

Ndi imodzi mwa mndandanda wa 3-amino-4-substituted pyrazole.Ikhoza kugwiritsidwa ntchito ngati yapakatikati kuti ipangitse mankhwala ambiri a pharmacologically ogwira ntchito, monga allopurinol, imodzi mwa mndandanda wa pyrazolopyrimidine, wotsirizira kuyambira 1963 Chiyambire kugwiritsidwa ntchito kwachipatala, wakhala mankhwala akuluakulu ochizira gout.Pakalipano, pali njira zochepa zodziwika zopangira synthesizing

3-aminopyrazole-4-carboxamide hemisulfate ku China, makamaka pochita malononitrile ndi triethyl orthoformate kukonzekera ethoxymethylene malononitrile, ndiyeno ndi Zomwe hydrazine hydrate zimatulutsa 3-amino-4-cyanopyrazole, zomwe pamapeto pake zimakhudzidwa ndi asidi wambiri kuti apange sulfuric acid.

3-aminopyrazole-4-carboxamide hemisulfate (Chen Huiru, Xiao Guomin et al. 3-aminopyrazole- Synthesis of 4-formamide hemisulfate [J]. Chemical Industry Times, 2008, 6 (22): 39 40), zokolola zonse za kaphatikizidwe ndi njirayi ndi pafupifupi 60% (yowerengedwa ngati malononitrile), njira iyi Imaphatikizapo kuchitapo kanthu katatu, masitepewo amakhala otalika, ndipo ma reagents omwe amagwiritsidwa ntchito, monga malononitrile ndi ethoxymethylene malononitrile, ndi owopsa komanso okwera mtengo.Kuonjezera apo, 3-aminopyrazole-4 yokonzedwa ndi njira iyi - Formamide hemisulfate ili ndi mtundu umene ndi wovuta kuchotsa ndipo umafunika kukonza zina, zomwe zimakhala zovuta kwambiri.

Pali malipoti m'mabuku akunja omwe amagwiritsa ntchito pyridylamide hydrazone ndi ethoxymethylene malononitrile monga zopangira kuti apeze 3-amino-4-cyanopyrazole powonjezera ndi cyclization, ndiyeno amachitapo kanthu ndi sulfuric acid yokhazikika kuti apeze cholinga (Reuken G Jones. Zochita za orthoesters ndi activemethylene mankhwala [J] J Am Chem Soc. 1952,74 (5): 4889 4891).Zida zazikulu zomwe zimagwiritsidwa ntchito munjira iyi ndizokwera mtengo, zokolola zomwe zimachita sizokwera, ndipo phindu la kupanga mafakitale ndilotsika.Ziyenera kukhala zovuta.

Executive Standard:Enterprise Standard
Kunja:Ufa woyera kapena wachikasu

Phukusi:25kg / ng'oma
assay (HPLC) zomwe zili zazikulu kuposa kapena zofanana ndi 98.0%
chiyero (HPLC) zomwe zili Zoposa kapena zofanana ndi 99.5%

JIN DUN Medical ali ndiKuyenerera kwa ISO ndikukwaniritsa miyezo ya GMP yopanga, olemba ntchito akatswiri apakhomo ndi akunja opangira mankhwala omwe ali ndi luso lotsogolera R&D yamakampani.

Ubwino wa TECHNOL OGY
● High Pressure Catalytic Hydrogenation .High Pressure Hydrogenolysis Reaction .Kusintha kwa Cryogenic (<-78%C)
●Aromatic Heterocyclic Synthesis
●Kukonzekeranso
● Chiral Resolution
●Heck, Suzuki,Negishi,Sonogashira .Gignard Reaction

Zida

Labu yathu ili ndi zida zosiyanasiyana zoyesera ndi kuyesa, monga: NMR (Bruker 400M), HPLC, chiral-HPLC, LC-MS, LC-MS/MS (API 4000), IR, UV, GC, GC-MS, Chromatography, Microwave Synthesizer, Parallel Synthesizer, Differential Scanning Calorimeter (DSC), Electron microscope…

Gulu la R&D

Jindun Medical ili ndi gulu la akatswiri a R&D, ndipo amagwiritsa ntchito akatswiri ambiri opangira mankhwala apakhomo ndi akunja kuti aziwongolera R&D, kupangitsa kuti kaphatikizidwe kathu kakhale kolondola komanso kothandiza.

Tathandiza makampani angapo apamwamba apanyumba azachipatala, mongaHansoh, Hengrui ndi HEC Pharm.Apa tikuwonetsa gawo lawo.

Kusintha Mwamakonda Mlandu Woyamba:

Cas No.: 110351-94-5

Mwamakonda Mlandu Wachiwiri:

Cas No.: 144848-24-8

Kusintha Mwamakonda Mlandu Wachitatu:

Cas No.: 200636-54-0

1.Sinthani Mwamakonda Anu Apakati kapena ma API.Monga momwe tafotokozera pamwambapa, makasitomala ali ndi zofuna za Intermediates kapena ma API, ndipo sangapeze zomwe zimafunikira pamsika, ndiye titha kuthandiza Kusintha Mwamakonda Anu.

2.Kukhathamiritsa kwa Zinthu Zakale.Gulu lathu lithandizira Kukulitsa ndi kukonza zopanga zotere zomwe njira yake ndi yakale, mtengo wopangira ndi wokwera, ndipo magwiridwe ake ndi otsika.Titha kupereka zolembedwa zonse za kutengerapo kwaukadaulo ndi kukonza njira, kuthandiza kasitomala kuti apange bwino.

Kuchokera ku zolinga za mankhwala kupita ku INDs, JIN DUN Medical amakupatsiraninjira imodzi yokhayokha ya R&D.

JIN DUN Medical amaumirira kupanga gulu lokhala ndi maloto, kupanga zinthu zolemekezeka, zanzeru, zolimba, ndikupita zonse kuti mukhale bwenzi lodalirika komanso bwenzi lamakasitomala!

Poganizira mawuwa, tsopano takhala m'gulu la opanga mwaukadaulo, otsika mtengo, komanso opikisana pamitengo ya Wholesale Hot Selling Ibrutinib Intermediates N-3 CAS 330792-70-6, Tikuyembekezera kukupatsirani zinthu zathu posachedwa, ndipo mupeza kuti mawu athu ndi omveka bwino komanso mtundu wazinthu zathu ndizabwino kwambiri!
Malo ogulitsaChina Ibrutinib N-3 ndi Intermediates, Pakalipano malonda athu atumizidwa kum'mawa kwa Ulaya, Middle East, Southeast, Africa ndi South America etc. Tili ndi malonda a 13years akatswiri ogulitsa ndi kugula m'magawo a Isuzu kunyumba ndi kunja komanso umwini wa makina amakono a Isuzu apakompyuta.Timalemekeza mkulu wathu wamkulu wa Kuonamtima mubizinesi, kukhala patsogolo pautumiki ndipo tichita zonse zomwe tingathe kuti tipatse makasitomala athu zinthu zapamwamba kwambiri komanso ntchito yabwino kwambiri.