1.Shanghai idakhazikitsa mankhwala achi China omwe ali ndi patent ndi kukonzekera kosavuta komanso chithandizo chosagwiritsa ntchito mankhwala kuti athandize anthu kulimbana ndi chimfine cha masika.
Shanghai Municipal Administration of Traditional Chinese Medicine idawulula pa 5 kuti National Base for the Prevention and Control of Chinese Medicine Epidemic Diseases (Shanghai) idatsogola popanga China Medicine Prevention and Control Plan ya 2023 Spring Influenza ku Shanghai (Mayesero) (pamenepa amatchedwa dongosolo), adapempha kumvetsetsa kwamankhwala achi China pa fuluwenza, adapanga malangizo amankhwala achi China kwa akulu ndi ana kutengera kusiyanasiyana kwa matenda, ndipo adayambitsa mankhwala angapo achikhalidwe achi China omwe ali ndi patent ndi kukonzekera kosavuta komanso njira zochiritsira zosagwiritsa ntchito mankhwala pofuna kupewa ndi kuwongolera fuluwenza. .
M'nyengo yozizira ndi masika, nyengo imakhala yotentha komanso yozizira, kusiyana kwa kutentha pakati pa usana ndi usiku kumasinthasintha, ndipo matenda opatsirana a nyengo alowa m'nthawi ya mliri komanso nthawi ya mliri.Posachedwapa, chiwerengero cha odwala chimfine A ndi matenda ena omwe alandiridwa ndi zipatala zazikulu ku Shanghai chawonjezeka.Ndondomekoyi cholinga chake ndi kupereka sewero lathunthu ku makhalidwe ndi ubwino wa mankhwala achi China popewa ndi kuchiza fuluwenza.
Zhang Wei, m'modzi mwa omwe adalemba dongosololi, wachiwiri kwa mtsogoleri wa COVID-19 Expert Group for Traditional Chinese Medicine Treatment and director of the Pulmonary Disease Department of Shuguang Hospital, akukhulupirira kuti chitukuko cha fuluwenza (fuluwenza) nthawi zambiri ndiwekha. kuchepetsa.Ana ena ofooka ndi okalamba omwe ali ndi matenda oyambitsa matenda angayambitse zovuta zina chifukwa cha matenda achilendo, omwe ndi cholinga cha kupewa ndi kuchiza mankhwala achi China ndi mankhwala akumadzulo.Iye anauza atolankhani kuti chikhalidwe Chinese mankhwala amakhulupirira kuti fuluwenza ndi gulu panopa ozizira.Malinga ndi kumvetsa chikhalidwe, matenda ndi mankhwala makamaka zochokera dongosolo kusiyanitsa syndrome ndi njira mankhwala a meridians zisanu ndi chimodzi, syndrome kusiyana kwa Weiqi ndi Yingxue, ndi syndrome kusiyana dongosolo ndi mankhwala njira ya jiao atatu, ndi chidwi. amalipidwa kwa kuphatikiza ntchito kulimbikitsa ndi kuchotsa zinthu tizilombo toyambitsa matenda ndi magawo ndi magawo.
"Fuluwenza nthawi zambiri imadziletsa ndipo imatha kuchiritsidwa pakangopita nthawi yochepa mutalandira chithandizo chamankhwala komanso TCM."Zhang Wei ananena kuti, kuwonjezera pa chikhalidwe Chinese patent mankhwala ndi kukonzekera yosavuta analimbikitsa chiwembu, akuluakulu TCM zipatala ku Shanghai ndi wolemera mu matenda ndi kuchiza fuluwenza, komanso mndandanda wa kukonzekera chipatala ndi mankhwala.
Akuti kufala kwaposachedwa kumakhala makamaka H1N1.Poyerekeza ndi chimfine, n’chopatsirana kwambiri, chimakhala ndi kutentha thupi kwambiri ndipo chimatenga nthawi yaitali, chimakhala ndi zizindikiro zoonekeratu za m’thupi, ndipo chimakhala ndi nthawi yaitali ya matenda.
Xue Zheng, mlembi wa Pulogalamu ya Ana komanso mkulu wa dipatimenti ya Pediatrics ku Shanghai Municipal Hospital of Traditional Chinese Medicine, amakhulupirira kuti ana ochepera zaka 5 amatha kutenga chimfine.Ana amatha kudwala chimfine ndipo amakhala ndi zizindikiro zoopsa chifukwa cha mapapu awo osalimba.Traditional Chinese mankhwala mbali yabwino kwambiri kupewa ndi kuchiza fuluwenza ana, makamaka pa matenda a fuluwenza A, amene ziletsa kufala ndi kuya kwa HIV, mofulumira kusintha zizindikiro, ndipo ali sipekitiramu yotakata.Matenda a ana m'zipatala zazikulu zaku China ndi Kumadzulo amakhalanso ndi zokonzekera zachipatala zokhwima zomwe zimagwiritsidwa ntchito kwambiri kuchipatala.
Dongosolo wapanga chikhalidwe Chinese mankhwala pangano mankhwala ndi chikhalidwe Chinese patent mankhwala ndi kukonzekera zosavuta ana mankhwala fuluwenza, komanso akufuna mndandanda wa njira zosavuta ndi zotsika mtengo kunja mankhwala a chikhalidwe Chinese mankhwala.Makolo atha kuchitapo kanthu pamankhwala achi China kudzera njira zamankhwala zakunja monga dietotherapy, kutikita minofu, makutu, kugwiritsa ntchito ndi zofukiza pendant kuthandiza ana kusintha zizindikiro mwachangu ndikuchira msanga.
2.Ofufuza asayansi adapeza zosakaniza zotsutsana ndi hepatoma zochokera ku chomera chamankhwala Artemisia annua.
Kunming Institute of Botany, Chinese Academy of Sciences, idalengeza pa 21 kuti gulu lofufuza la Chen Jijun lapeza ma dimers angapo a sesquiterpene okhala ndi anti khansa ya chiwindi kuchokera ku chomera chamankhwala Artemisia scoparia.Zotsatira za kafukufuku wofunikira zidasindikizidwa posachedwa mu nyuzipepala yotchuka yapadziko lonse lapansi yotchedwa Signal Transmission and Targeted Therapy.
Khansara ya chiwindi ndi chotupa chowopsa chomwe chimawopseza kwambiri thanzi la munthu.Chaka chilichonse, chiwerengero cha matenda atsopano a khansa ya chiwindi padziko lapansi chimaposa 840000, ndipo chiwerengero cha imfa chifukwa cha khansa ya chiwindi chimafika 780000, pamene pafupifupi 50% ya milandu yatsopano imachitika ku China.Pakalipano, pali tyrosine kinase inhibitors, sorafenib, regafinil, lovatinib ndi cabotinib, mdani wina wa vascular endothelial growth factor receptor 2, ramolumab, ndi PD-1 inhibitors, navumab ndi pamuzumab, omwe amagwiritsidwa ntchito pochiza khansa ya chiwindi. , koma mawonekedwe ake ndi osavuta komanso osavuta kupanga osamva mankhwala.
M'zaka zaposachedwa, gulu la kafukufuku la Chen Jijun lakhala likudzipereka kufunafuna mankhwala oletsa hepatoma ndi mankhwala atsopano omwe ali ndi mawonekedwe apadera komanso njira zatsopano zogwirira ntchito kuchokera ku zomera za Artemisia, ndipo akhazikitsa bwino njira yolekanitsa yophatikizira kuzindikira kwa njira ya sesquiterpene dimers ku Artemisia. Zomera zomwe zimatsata ntchito za anti-hepatoma.Kafukufukuyu anapeza kwa nthawi yoyamba kuti Tingafinye wa Artemisia annua ali amphamvu chopinga ntchito pa maselo atatu hepatoma, ndipo kwa nthawi yoyamba, 36 buku sesquiterpene dimers a 9 structural mitundu - Artemisia annua A1-A3, B1-B2, C1-C4 , D, E, F1-F15, G1-G8, H ndi ine tinalekanitsidwa ndi gawo logwira ntchito la Artemisia annua.
Kufufuza kwina kunasonyeza kuti pakati pa 36 novel sesquiterpene dimers, ntchito ya artemisinin G5 ndi G7 inali yabwino kwambiri, yomwe inali yofanana ndi mankhwala oyambirira a anti-hepatoma mankhwala sorafenib;Komanso, kum'mwera artemisinin G7 anasonyeza bwino selectivity ndi chitetezo kuposa sorafenib kwa THLE-2 mu maselo yachibadwa chiwindi;Panthawi imodzimodziyo, kum'mwera kwa artemisinin G7 kungathenso kulepheretsa kuchuluka kwa maselo a HepG2 mwa kulepheretsa kulowetsedwa ndi kusamuka kwa maselo a hepatoma, kuchititsa apoptosis ndi kutsekereza G2/M cell cycle.
Kafukufukuyu adavumbulutsa kwa nthawi yoyamba ma dimers angapo a sesquiterpene okhala ndi mafupa atsopano komanso mawonekedwe osiyanasiyana ku Artemisia annua, adalimbikitsa mitundu yamapangidwe a sesquiterpene dimers muzomera za Artemisia, ndipo adapereka mamolekyu osiyanasiyana osankhidwa ndi maziko ofunikira azachipatala pofufuza za anti - hepatoma mankhwala.
Mpaka pano, gulu lofufuza la Chen Jijun lapatula ndikuzindikira ma dimers 122 a sesquiterpenoid omwe ali ndi anti-hepatoma zochita kuchokera ku Artemisia australis, Artemisia sinica, Artemisia menalis, Artemisia cowtail ndi Artemisia Mongolica, kuwerengera 52% ya chiwerengero chonse cha 234 dismer Zomera za Artemisia padziko lapansi.
JinDun Medicalali ndi mgwirizano wanthawi yayitali wofufuza zasayansi komanso kulumikiza ukadaulo ndi mayunivesite aku China.Ndi chithandizo chamankhwala cholemera cha Jiangsu, ili ndi ubale wautali wamalonda ndi India, Southeast Asia, South Korea, Japan ndi misika ina.Imaperekanso ntchito zamsika ndi zogulitsa munjira yonse kuyambira apakatikati mpaka kumaliza API.Gwiritsani ntchito zomwe zasonkhanitsidwa za Yangshi Chemical mu chemistry ya fluorine kuti mupereke ntchito zapadera zosinthira makonda kwa anzanu.Perekani njira zatsopano zogwirira ntchito ndi ntchito zofufuza zonyansa kwa makasitomala.
JinDun Medical akuumirira pakupanga gulu lokhala ndi maloto, kupanga zinthu mwaulemu, mosamala, mosamalitsa, ndikupita zonse kuti mukhale bwenzi lodalirika komanso bwenzi lamakasitomala! akatswirimakonda kupanga mankhwala(CMO) ndi othandizira opangira mankhwala a R&D ndi kupanga (CDMO).
Nthawi yotumiza: Mar-30-2023