Sabata ino, nyuzipepala yapamwamba kwambiri yamaphunziro a Nature idasindikiza pepala lofufuza pa intaneti lopangidwa ndi gulu la Pulofesa Feng Liang ku yunivesite ya Stanford, kuwulula kapangidwe kake komanso kagwiritsidwe ntchito ka puloteni yotchinga magazi muubongo MFSD2A.Kupezeka kumeneku kumathandizira kupanga mankhwala owongolera kufalikira kwa chotchinga chamagazi-muubongo.
MFSD2A ndi chotengera cha phospholipid chomwe chimapangitsa kuti docosahexaenoic acid ilowe muubongo m'maselo a endothelial omwe amapanga chotchinga chamagazi-muubongo.Docosahexaenoic acid imadziwika bwino ndi dzina loti DHA, yomwe ndiyofunikira pakukula komanso kugwira ntchito kwa ubongo.Kusintha komwe kumakhudza ntchito ya MFSD2A kungayambitse vuto lachitukuko lotchedwa microcephaly syndrome.
Mphamvu yoyendetsa lipid ya MFSD2A imatanthawuzanso kuti puloteniyi imagwirizana kwambiri ndi kukhulupirika kwa chotchinga cha magazi ndi ubongo.Kafukufuku wam'mbuyomu adapeza kuti ntchito yake ikachepetsedwa, chotchinga chamagazi-muubongo chidzatuluka.Chifukwa chake, MFSD2A imawonedwa ngati chosinthira cholonjezedwa chodalirika pakafunika kuwoloka chotchinga chamagazi-muubongo kuti upereke mankhwala achire muubongo.
Mu kafukufukuyu, gulu la Pulofesa Feng Liang linagwiritsa ntchito ukadaulo wa cryo-electron microscopy kuti apeze mawonekedwe apamwamba a mbewa ya MFSD2A, kuwulula malo ake apadera a extracellular ndi gawo lapansi lomanga.
Kuphatikiza kusanthula kwa magwiridwe antchito ndi kuyerekezera kwamphamvu kwa ma cell, ofufuzawo adazindikiranso malo osungidwa a sodium mumpangidwe wa MFSD2A, kuwulula njira zolowera m'magazi, ndikuthandizira kumvetsetsa chifukwa chake kusintha kwa MFSD2A kumayambitsa matenda a microcephaly.
Nthawi yotumiza: Sep-01-2021