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MOQ Yotsika Yogulitsa Kwambiri!Factory Supply High Quality Betrixaban Raw Materials CAS 330942-05-7

MOQ Yotsika Yogulitsa Kwambiri!Factory Supply High Quality Betrixaban Raw Materials CAS 330942-05-7

Kufotokozera Kwachidule:


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Zolemba Zamalonda

Kukhala gawo lokwaniritsa maloto a antchito athu!Kuti mupange gulu losangalala, logwirizana komanso lowonjezera la akatswiri!Kuti tipeze mphotho ya ogula athu, ogulitsa, gulu komanso ife tokha pa Low MOQ for Hot Sale!Factory Supply High Quality Betrixaban Raw Materials CAS 330942-05-7, Ndife oona mtima komanso omasuka.Timayang'ana kutsogolo ndikukhazikitsa ubale wodalirika komanso wokhalitsa wachikondi.
Kukhala gawo lokwaniritsa maloto a antchito athu!Kuti mupange gulu losangalala, logwirizana komanso lowonjezera la akatswiri!Kuti tipeze mphotho ya ogula, ogulitsa, gulu ndi ife tokhaChina Pharmaceutical Intermediate ndi 330942-05-7, "Zabwino komanso mtengo wololera" ndizo mfundo zathu zamabizinesi.Ngati mukufuna mayankho athu kapena muli ndi mafunso, kumbukirani kuti omasuka kulankhula nafe.Tikuyembekeza kukhazikitsa maubwenzi ogwirizana ndi inu posachedwa.

Fondaparinux Biological Activity

Fotokozani Fondaparinux sodium ndi antithrombin-dependent factor Xa inhibitor.
ZogwirizanaMagulu njira yolumikizira >> Ma enzyme/mapuloteni >> Magawo ofufuza a Factor Xa >> Matenda amtima
Zolinga Factor Xa[1]
Mu vitromaphunziro Fondaparinux sodium ndiye anticoagulant yatsopano yoyamba yomwe imayang'ana factor Xa.Kwa Fondaparinux, mtengo wa IC50 (anti-Xa IU/ml) wa activated monocytes (ac-M) ndi 0.59±0.05, ndi tinthu tating'ono ta monocyte (MMP) ndi 0.17±0.03 [2].
Mu vivokafukufuku Fondaparinux sodium ili ndi mzere wodalira pharmacokinetic mbiri, yomwe imapereka yankho lodziwikiratu.Fondaparinux sodium imakhala ndi 100% bioavailability, imayamba mwachangu, imakhala ndi theka la moyo wa maola 14 mpaka 16, ndipo imatha kupitiliza kukana thrombosis mkati mwa maola 24.Mankhwalawa samakhudza nthawi ya prothrombin kapena nthawi yayitali ya thromboplastin, komanso samakhudza ntchito ya mapulateleti kapena kuphatikiza [1].
Maumboni [1].Bauer KA.ndi al.Fondaparinux sodium: choletsa chosankha cha factor Xa.Am J Health Syst Pharm.2001 Nov 1;58 Zowonjezera 2:S14-7.[2].Ben-Hadj-Khalifa S, et al.Kusiyana kwa coagulation inhibitory zotsatira za fondaparinux, enoxaparin ndi heparin yosagwirizana m'maselo amtundu wa thrombin.Magazi a Coagul Fibrinolysis.2011 Jul; 22 (5): 369-73.

Chemical ndi thupi katundu wa Fondaparinux

Mapangidwe a maselo C31H53N3Na10O49S8
Kulemera kwa maselo 1738.16
PSA 900.82000

Fondaparinux ndi mtundu watsopano wa mankhwala a antithrombotic omwe avomerezedwa ndi FDA pambuyo pa heparin ndi heparin yotsika kwambiri ya molekyulu yochizira komanso kupewa matenda osiyanasiyana a arteriovenous thrombosis.

Fondaparinux amagwiritsidwa ntchito kwa odwala omwe akuchitidwa opaleshoni yayikulu ya mafupa a miyendo yapansi, monga kuthyoka kwa m'chiuno, opaleshoni yaikulu ya bondo kapena kubwezeretsa m'chiuno, kuteteza venous thromboembolism.Amagwiritsidwa ntchito pochiza odwala omwe ali ndi angina osakhazikika kapena omwe si a ST-segment elevation myocardial infarction omwe amapita mwamsanga (<120 minutes) invasive treatment (PCI) popanda kusonyeza.Amagwiritsidwa ntchito pochiza odwala omwe ali ndi ST-segment elevation myocardial infarction omwe amagwiritsa ntchito thrombolysis kapena samalandila mitundu ina ya chithandizo chamankhwala.

1) Kukwezeleza msika Glaxo mosalekeza adzaika mu pachimake mankhwala udindo mu zotsatira zachipatala njira ya Unduna wa Zaumoyo, kusintha mitengo ya National Development and Reform Commission, ndi inshuwaransi zachipatala za Ministry of People's Insurance.

A, Chogulitsacho sichinalowebe mu inshuwaransi yachipatala ya dziko.Mu 2010, kusintha kwa inshuwaransi yachipatala kwangolowa kumene ku inshuwaransi yazachipatala ya m'maboma 16.Zogulitsa zili poyambira ndipo pang'onopang'ono zidzalowa m'malo mwa msika wa heparin wochepa kwambiri;zigawo za inshuwaransi zachipatala: Shaanxi, Shanxi, Inner Mongolia, Liaoning, Tibet, Yunnan, Guangdong, Guangxi, Hainan, Jiangsu, Gansu, Fujian, Jiangxi, Henan, Hubei, Beijing.

B, Zizindikiro zikuwonjezeka.GSK pakadali pano ili ndi zizindikiro za 3 kuchipatala.Mwachitsanzo, zisonyezo za ma stents zimavomerezedwa kokha.Ma heparin ena sapezeka.Kugwiritsidwa ntchito kwachipatala kwa stents kumawonjezeka ndi 30% chaka chilichonse.Ndi chivomerezo cha zizindikiro zatsopano, malonda adzawonjezeka.M'malingaliro, matenda onse omwe amathandizidwa ndi mankhwala a heparin amatha kuthandizidwa ndi mankhwalawa.

C, Mtengo wamtengo wapatali, mtengo wotsika wa mankhwalawa pamsika wa US ndi madola 132 US aliyense, ku China ndi 168 yuan, mtengo wapakhomo sudzatsika.Ngati mutumiza kunja, msika wapadziko lonse lapansi uli ndi malo otakata;

2) Chiwopsezo chaukadaulo ndichokwera, zopangira zimapangidwira masitepe 75, ndipo chilolezo chatha zaka 5 (nkhani mu 2014).Sizinavomerezedwe ndi opanga ena.The synthesis ndizovuta kwambiri.Sizidzachitika pasanathe zaka 10.Ulendowu ndi wautali, wovuta, komanso wosunga ndalama.apamwamba.Pali opikisana nawo ochepa apakhomo, ndipo opikisana nawo akunja ali ndi ndalama zambiri zopangira.Cholinga chathu ndi kuchepetsa ndalama zopangira ndikusintha Glaxo pakupanga zopangira.
Hengrui Pharmaceuticals Fondaparinux idavomerezedwa ngati kutsanzira koyamba ku China 2018.
Guangdong Runxing Biotechnology Co., Ltd. ili ndi zotulutsa zapachaka za 210 kg za fondaparinux sodium advanced intermediate N3, zomwe zidzasungidwe mu 2018.

Fondaparinux idapangidwa koyambirira ndi MYLAN IRELAND.Pakadali pano, Hengrui Pharmaceuticals, Borui Pharmaceuticals, Haisco.

Kukhala gawo lokwaniritsa maloto a antchito athu!Kuti mupange gulu losangalala, logwirizana komanso lowonjezera la akatswiri!Kuti tipeze mphotho ya ogula athu, ogulitsa, gulu komanso ife tokha pa Low MOQ for Hot Sale!Factory Supply High Quality Betrixaban Raw Materials CAS 330942-05-7, Ndife oona mtima komanso omasuka.Timayang'ana kutsogolo ndikukhazikitsa ubale wodalirika komanso wokhalitsa wachikondi.
Low MOQ kwaChina Pharmaceutical Intermediate ndi 330942-05-7, "Zabwino komanso mtengo wololera" ndizo mfundo zathu zamabizinesi.Ngati mukufuna mayankho athu kapena muli ndi mafunso, kumbukirani kuti omasuka kulankhula nafe.Tikuyembekeza kukhazikitsa maubwenzi ogwirizana ndi inu posachedwa.


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