Guanosine

Guanosine amagwiritsidwa ntchito ngati wapakatikati wa Valaciclovir.
Valacyclovir ndi guanine analogue antiviral mankhwala.Amagwiritsidwa ntchito pochiza matenda a herpes simplex ndi herpes zoster matenda opatsirana pogonana.Izi ndi kalambulabwalo wa acyclovir.Imatengeka mwachangu pambuyo pa makonzedwe amkamwa ndipo imasandulika kukhala acyclovir m'thupi.Mphamvu yake yoletsa ma virus imaseweredwa ndi acyclovir.Pambuyo acyclovir akulowa nsungu HIV maselo, amapikisana ndi deoxynucleoside kwa HIV thymidine deoxynucleoside kinase kapena selo kinase, ndi mankhwala phosphorylated mu adamulowetsa acyclic guanosine triphosphate.Monga gawo lapansi la kugawanika kwa kachilomboka, acyclovir amapikisana ndi deoxyguanine triphosphate kwa kachilombo ka DNA polymerase, yomwe imalepheretsa kaphatikizidwe ka DNA ndikuwonetsa antiviral kwenikweni.The sapha mavairasi oyambitsa ntchito ya mankhwala mu vivo ndi bwino kuposa acyclovir, ndi mankhwala index a nsungu simplex HIV mtundu I ndi mtundu II ndi 42,91% ndi 30,13% apamwamba kuposa acyclovir motero.Ilinso ndi mphamvu yochiritsa kwambiri pa varicella zoster virus.