Ethylmethyl-carbamic kloride

Ethylmethyl-carbamic chloride amagwiritsidwa ntchito ngati wapakatikati wa Rivastigmine tartrate.
Rivastigmine tartrate ndi rivastigmine matenda a Alzheimer's mankhwala, rivastigmine ndi physostigmine yotengedwa ndi Novartis kwa nthawi yoyamba bwinobwino anayamba malonda dzina Exelon (exelon), molekyulu ndi apo carbamate dongosolo, ndi mtundu wa amino acid wa kusankha cerebral cholinesterase inhibitor, angathenso kuletsa. The acetylcholinesterase ndi butyrylcholinesterase, cholinergic neurons mwa kuchedwetsa kutulutsa kwa acetylcholine kuwonongeka ndi mphamvu zomwe zimalimbikitsa cholinergic nerve conduction, zimatha kupititsa patsogolo kusokonezeka kwachidziwitso komwe kumalumikizidwa ndi cholinergic, potero kumathandizira kuzindikira kwa odwala matenda a Alzheimer's.Kumanga kwa mapuloteni a plasma a Rivastigmine ndi ofooka, mosavuta kupyolera mu chotchinga cha magazi-ubongo, chomwe chimakhala ndi kusankhidwa kwakukulu kwa ubongo.Sikuti imagwira ntchito pa cerebral cortex ndi hippocampus, komanso imalepheretsa mtundu waukulu wa AChE muubongo, zomwe zimapangitsa kuchepa kwa mphamvu ya zotumphukira za cholinergic.Rivastigmine mu vivo theka la moyo ndi lalifupi komanso lalitali lochitapo kanthu.Mosiyana ndi tacrine, mankhwalawa mu hippocampus ndi cortex ya G1 enzyme inhibitory effect ndi yamphamvu.Chipatala chochiza matenda a dementia wofatsa mpaka pang'ono, kapena matenda a Alzheimer's amatha kuganiziridwa kuti ndi matenda a Alzheimer's.