Entecavir USP Chidetso B;Aids098045;Aids-098045;Etv;Enticavir;EntikaweiPian;

Kufotokozera Kwachidule:

Tsatanetsatane wa Zamalonda

Zolemba Zamalonda

Kugwiritsa ntchito

Entecavir (SQ 34676;BMS 200475) ndi HBV Inhibitor yosankha komanso yothandiza.M'maselo a HepG2 EC50 mtengo ndi 3.75 nM.Mankhwala aposachedwa kwambiri othana ndi matenda a chiwindi a mtundu wa B komanso odana ndi Edzi.

Mphamvu ya Entecavir

Mankhwalawa ndi guanine nucleoside analogue, omwe ali ndi cholepheretsa pa hepatitis B virus (HBV) polymerase.Itha kukhala phosphorylated kukhala triphosphate yogwira, ndipo theka la moyo wa triphosphate mu cell ndi maola 15.Mwa kupikisana ndi HBV polymerase's natural substrate deoxyguanosine triphosphate, entecavir triphosphate ikhoza kulepheretsa ntchito zonse zitatu za viral polymerase (reverse transcriptase): (1) HBV polymerase initiation;(2) pregenomic mRNA Kupanga kwa chingwe choyipa cha reverse transcript;(3) Kaphatikizidwe ka chingwe chabwino cha HBV DNA.The inhibitory constant (Ki) ya entecavir triphosphate pa HBV DNA polymerase ndi 0.0012μM.Entecavir triphosphate ili ndi mphamvu yofooka yolepheretsa selo α, β, δ DNA polymerase ndi mitochondrial γ DNA polymerase, ndi Ki mtengo wa 18 mpaka 160 μM.

Ma parameters

Fotokozani	Entecavir (SQ 34676;BMS 200475) ndi yosankha komanso yothandiza ya HBV Inhibitor.Mu ma cell a HepG2 EC50 mtengo ndi 3.75 nM.
Zogwirizanamagulu	chizindikiro njira >> Anti-infective >> HBV Research madera >> Infect
Zolinga	EC50: 3.75 nM (anti-HBV, HepG2 cell)[2]
Mu vitromaphunziro	EC50 ya BMS-200475 ku HBV ndi 3.75 nM.Imaphatikizidwa mu zoyambira zamapuloteni a HBV, ndiyeno gawo loyambira la reverse transcriptase limaletsedwa.Ntchito ya antiviral ya BMS-200475 ndiyotsika kwambiri kuposa ma virus ena a RNA ndi DNA [1].Poyerekeza ndi zina zofananira za deoxyguanosine (penciclovir, ganciclovir, lobucavir ndi acyclovir) kapena lamivudine, entecavir imatha kukhala phosphorylated ku metabolite yake yogwira.Theka la moyo wa Entecavir ndi maola 15 [2].
Mu vivokafukufuku	BMS-200475 imachiritsidwa pamlomo tsiku ndi tsiku ndi mlingo wochokera ku 0.02 mpaka 0.5 mg / kg kulemera kwa thupi kwa miyezi 1 mpaka 3, yomwe ingachepetse bwino mlingo wa woodchuck hepatitis virus (WHV) viremia mu woodchucks matenda [3].
Selokuyesa	BMS 200475 imakonzedwa mu phosphate buffered saline (PBS) ndi kuchepetsedwa ndi sing'anga yoyenera yokhala ndi 2% fetal bovine serum.HepG2 2.2.15 maselo seeded pa 12-chitsime Biocoat kolajeni TACHIMATA mbale pa kachulukidwe wa 5 × 10 5 maselo pa chitsime, ndipo anali mu confluent boma kwa 2 kwa masiku 3, ndiyeno yokutidwa ndi 1 mL wa BMS 200475 zapakati .Kuwerengera kwa HBV kunachitika pa tsiku la 10 [1].
Maumboni	[1].Innaimo SF, et al.Kuzindikiritsa BMS-200475 ngati choletsa champhamvu komanso chosankha cha kachilombo ka hepatitis B.Antimicrob Agents Chemother.1997 Jul;41(7):1444-9.[2].Rivkin A, ndi al.Ndemanga ya entecavir pochiza matenda aakulu a hepatitis B.Curr Med Res Opin.2005 Nov; 21 (11): 1845-57 [3].Genovesi EV, et al.Kuchita bwino kwa carbocyclic 2'-deoxyguanosine nucleoside BMS-200475 mu mtundu wa woodchuck wa matenda a hepatitis B.Antimicrob Agents Chemother.1998 Dec;42(12):3209-18.

Thupi ndi mankhwala katundu wa Entecavir

Kuchulukana	1.8±0.1 g/cm³
Malo otentha	734.2ºC pa 760 mmHg
Malo osungunuka	249-252ºC
Mapangidwe a maselo	C12H15N5O3
Kulemera kwa maselo	277.279
pophulikira	397.9ºC
Khalidwe lenileni	277.117493
PSA	130.05000
LogP	-0.96
Mawonekedwe ake	Choyera mpaka choyera/chikaso cha crystalline ufa
Refractive index	1.837
Zosungirako	-20 ° C Mufiriji

Entecavir Customs

Customs kodi	2933990099
Chidule cha China	2933990099. Mankhwala ena a heterocyclic okhala ndi ma heteroatomu a nayitrogeni okha.Mtengo wowonjezera wa msonkho: 17.0%.Mtengo wochotsera msonkho: 13.0%.Zowongolera: Palibe.Mtengo wamtundu womwe umakomera kwambiri: 6.5%.General tariff: 20.0%
Zolengeza	Dzina mankhwala, pophika okhutira, ntchito hexamethylene kolorayidi, chonde onetsani maonekedwe, 6-caprolactam, chonde onetsani maonekedwe, kusaina tsiku.
Chidule	2933990090. heterocyclic mankhwala okhala ndi nitrogen hetero-atomu (ma) okha.VAT: 17.0%.Mtengo wochotsera msonkho: 13.0%..Mtengo wa MFN: 6.5%.General tariff: 20.0%

Zina Zowonjezera:

Qu Qiang (PhD muchipatala chachipatala, Dipatimenti ya Pharmacy, Xiangya Hospital, Central South University) ndi Wang Ruoguang (Doctor of Medicine, postdoctoral in biology, Changsha Ruoguang Medical Research Center) analembanso kuti: mu regimen ya entecavir, entecavir ikhoza kutengedwa. kwa zaka zingapo kapena zaka 10.Kuposa zaka.Ndipo ingagwiritsidwe ntchito ndi amayi apakati, kusonyeza chitetezo chabwino.

Potengera njira zomwe zimadziwika kuti mamolekyulu a pharmacological, Entecavir ikhoza kukhala ndi anti-spectrum antiviral effect, osati yolimbana ndi HBV yokha.

Nthawi zambiri timagwiritsa ntchito Entecavir kuti tithetse matenda opatsirana pogwiritsa ntchito mavairasi kuchipatala, ndipo zotsatira zake ndi zodabwitsa.

Pakadali pano, pakuwunikanso kwa odwala opitilira 500 a COVID19 ku Hubei (malo), munthu m'modzi yekha adatenga entecavir.Nthawi yolembera inali kumayambiriro kwa Januware, ndiyeno mankhwalawa adayimitsidwa.

Pomwe akuthandizira ogwira ntchito zachipatala ku Hubei, madotolo ena akumidzi, kapena magulu omwe ali pachiwopsezo chachikulu, omwe akugwiritsa ntchito Entecavir kupewa COVID19, palibe vuto la matenda.Anthu omwe akuganiziridwa kuti akumwa entecavir, palibe amene wapita patsogolo kuti apezeke ndi COVID19.

Mavuto a Patent:

Pali njira ziwiri, 06 ndondomeko ndi ndondomeko 89.Kutha kwa patent kwa njira ya 06 ndikoyambika kwambiri (kutha mu 2023)!Ngakhale kuti mtengo wa ndondomekoyi ndi wotsika, khalidweli ndi labwino, ndipo ogwira ntchito akhoza kukhala amphamvu, malangizo aumwini: Kwa zomera za mankhwala, gwiritsani ntchito ndondomeko ya 06 kuti musakhale odzikuza;kwa makampani opanga mankhwala, musatengeke ndipo musakhale owopsa kwambiri.

Mu 2014, Chia Tai Tianqing adapeza malonda a pachaka a 10 biliyoni ya yuan podalira mankhwala osokoneza bongo monga entecavir, omwe entecavir anali 20%.

Popeza kuti entecavir inavomerezedwa kuti ilowe mu 2005, makampani oposa 100 ogulitsa mankhwala apakhomo apempha kuti alembetse mankhwalawa;pakati pawo, makampani ovomerezeka opangira mankhwala akuphatikizapo Jiangsu Zhengda Tianqing Pharmaceutical (kutsanzira koyamba), Hainan Zhonghe Pharmaceutical, ndi Fujian Guangxi Pharmaceutical Co., Ltd. Shengtang Pharmaceutical, Jiangxi Qingfeng Pharmaceutical, Suzhou Dawnrays Pharmaceutical, Shanghai Downrays Pharmaceutical, Singchung. Lukang, Zhejiang Huasheng Biopharmaceutical, Changzhi Sanbao Biochemical.

Pharmaceutical, Anhui Baker Biopharmaceutical, Hunan Concord Pharmaceutical Industry, Beijing Xiehe Pharmaceutical Factory, Beijing Baiao Pharmaceutical, Xinlitai Pharmaceutical, Dongyangguang, etc.;kupitilira kuyambira tsiku la mgwirizano, mankhwalawa adalowa m'mitundu yodziwika bwino kuyambira 2007.

Resource-integrated Product Line

Satifiketi

JIN DUN Medical ali ndiKuyenerera kwa ISO ndikukwaniritsa miyezo ya GMP yopanga, olemba ntchito akatswiri apakhomo ndi akunja opangira mankhwala omwe ali ndi luso lotsogolera R&D yamakampani.

Ubwino pa Medical Customization

Ubwino wa TECHNOL OGY
● High Pressure Catalytic Hydrogenation .High Pressure Hydrogenolysis Reaction .Kusintha kwa Cryogenic (<-78%C)
●Aromatic Heterocyclic Synthesis
●Kukonzekeranso
● Chiral Resolution
●Heck, Suzuki,Negishi,Sonogashira .Gignard Reaction

JIN DUN R&D

Zida

Labu yathu ili ndi zida zosiyanasiyana zoyesera ndi kuyesa, monga: NMR (Bruker 400M), HPLC,chiral-HPLC,LC-MS,LC-MS/MS (API 4000),IR,UV,GC,GC,GC-MS, Chromatography, Microwave Synthesizer, Parallel Synthesizer, Differential Scanning Calorimeter (DSC), Electron microscope ...

Gulu la R&D

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Kugawana Mlandu

Tathandiza makampani angapo apamwamba apanyumba azachipatala, mongaHansoh, Hengrui ndi HEC Pharm.Apa tikuwonetsa gawo lawo.

Kusintha Mwamakonda Mlandu Woyamba:

Cas No.: 110351-94-5

Mwamakonda Mlandu Wachiwiri:

Cas No.: 144848-24-8

Kusintha Mwamakonda Mlandu Wachitatu:

Cas No.: 200636-54-0

Cooperation Mode

1.Sinthani Mwamakonda Anu Apakati kapena ma API.Monga momwe tafotokozera pamwambapa, makasitomala ali ndi zofuna za Intermediates kapena ma API, ndipo sangapeze zomwe zimafunikira pamsika, ndiye titha kuthandiza Kusintha Mwamakonda Anu.

2.Kukhathamiritsa kwa Zinthu Zakale.Gulu lathu lithandizira Kukulitsa ndi kukonza zopanga zotere zomwe njira yake ndi yakale, mtengo wopangira ndi wokwera, ndipo magwiridwe ake ndi otsika.Titha kupereka zolembedwa zonse za kutengerapo kwaukadaulo ndi kukonza njira, kuthandiza kasitomala kuti apange bwino.

Kuchokera ku zolinga za mankhwala kupita ku INDs, JIN DUN Medical amakupatsiraninjira imodzi yokhayokha ya R&D.

JIN DUN Medical amaumirira kupanga gulu lokhala ndi maloto, kupanga zinthu zolemekezeka, zanzeru, zolimba, ndikupita zonse kuti mukhale bwenzi lodalirika komanso bwenzi lamakasitomala!

Zam'mbuyo: p-Tolylcarboxylic acid;4-Toluic acid,99%;4-Carboxytoluene, p-Toluic acid;

Ena: FondaparinSodiumM;Fondaparinux Sodium Identification;Fondaparinux sodium N-4;

Lembani uthenga wanu apa ndikutumiza kwa ife