Casp ungin Acetate;Caspofungin acetate;Cancidas;Caspofungin acetate [USAN:BAN:JAN];
![Casp ungin Acetate;Caspofungin acetate;Cancidas;Caspofungin acetate [USAN:BAN:JAN];Chithunzi Chowonetsedwa](http://cdn.globalso.com/jindunchem-med/fbe17385.jpg)
Casp ungin Acetate;Caspofungin acetate;Cancidas;Caspofungin acetate [USAN:BAN:JAN];
Caspofungin Acetate Biological Activity
| Fotokozani | Caspofungin Acetate ndi mankhwala osokoneza bongo omwe sangalepheretse kuphatikizika kwa 1,3-β-d glucan synthase. |
| Zogwirizanamagulu | njira yolumikizira >> Anti-infective >> Bowa Research madera >> Infect |
| Mu vivokafukufuku | Makoswe obayidwa ndi caspofungin analibe kusintha kwakukulu mu mawonekedwe awo a ERG waveform pamtundu wa vitreous wa 0.41 mpaka 4.1 μM, ndipo retina yawo inalibe kusintha kwa morphological kapena kutayika kwa maselo.Pa vitreous ndende ya 41 μM, caspofungin inachepetsa matalikidwe a mafunde, b wave ndi scotopic threshold reaction ya ERG, komanso inachititsa kuchepa kwa chiwerengero cha maselo a ganglion cell layer [1].Carprofungin (8 mg/kg) kapena amphotericin B 1 mg/kg, jekeseni wa intraperitoneal kamodzi pa tsiku maola 30 pambuyo pa matenda kwa masiku 7 otsatizana, pokhudzana ndi chithandizo cha galimoto, kupulumuka kwa 100% pa tsiku la 28, zomwe zimachititsa kuti masana amafa 100% 11. , pambuyo pa vuto lopatsirana.Poyerekeza ndi chithandizo chamagalimoto pa tsiku la 5, caspofungin inachepetsa kuchira kwa Candida yotheka mu impso ndi minofu ya ubongo pamene katundu wolamulira anafika pachimake.Mbewa zothandizidwa ndi caspofungin pa mlingo wa 2 mg / kg kapena apamwamba zinali ndi ubongo wochepa kwambiri pa tsiku la 5 kusiyana ndi mbewa zomwe zimagwiritsidwa ntchito ndi amphotericin B. Amphotericin B ndi chithandizo cha caspofungin chinachepetsa matenda a fungal aimpso ndi 1.7 log CFU / g ndi 2.46 mpaka 3.64 log CFU /g, motero [2]. |
| Nyamakuyesa | Thandizo la antifungal lidayambika patatha maola 30 pambuyo pa vuto lopatsirana ndipo amaperekedwa ndi jakisoni wa intraperitoneal (ip) kamodzi patsiku kwa masiku 7.Mbewa zinachitidwa ndi 1, 2, 4, kapena 8 mg / kg / tsiku caspofungin, 1 mg / kg / tsiku amphotericin B kapena kuyendetsa galimoto (madzi osungunula osabala).Mphamvu ya chitsanzocho idawunikidwa m'njira zitatu: poyang'anira kuchuluka kwa moyo wa nyama za 10 m'gulu lililonse lamankhwala, poyang'anira katundu wa Candida mu impso ndi ubongo wa gulu lachiwiri la nyama zochiritsidwa, komanso poyesa impso.Ndipo ubongo.Gulu lachitatu la nyama zochitira.Makoswe adalimbikitsidwa ndi mpweya wa CO 2 ndipo amakula maola 30 (kuwongolera magalimoto okha) ndi tsiku la 5 (maola 24 pambuyo pa mlingo wa 4), 8 (maola 24 pambuyo pa mlingo womaliza), ndi 14, maola 21 ndi histological. sampuli za minofu.(Caspofungin mankhwala okha), ndipo 28 pambuyo kuukira. |
| Maumboni | [1].Mojumder DK, et al.Kuwunika poizoni wa retina wa intravitreal caspofungin m'diso la mbewa.Invest Ophthalmol Vis Sci.2010 Nov; 51(11): 5796-803. [2].Flattery, Amy M. et al.Kuchita bwino kwa caspofungin mu mtundu wa mbewa wachinyamata wapakati pa mitsempha ya candidiasis.Antimicrobial Agents ndi Chemotherapy (2011), 55 (7), 3491-3497. |
Chemical ndi thupi katundu wa caspofungin acetate
| Malo otentha | 1408.1ºC pa 760 mmHg |
| Mapangidwe a maselo | Chithunzi cha C56H96N10O19 |
| Kulemera kwa maselo | 1093.31000 |
| Khalidwe lenileni | 1092.64000 |
| PSA | 412.03000 |
| LogP | 0.06150 |
| Mawonekedwe ake | woyera mpaka beige |
| Kuthamanga kwa nthunzi | 0mmHg pa 25°C |
| Zosungirako | 20°C |
| Kusungunuka kwamadzi | H2O: soluble15mg/mL (njira yomveka bwino) |
Caspofungin Acetate Customs
| Customs kodi | 2933990099 |
| Chidule cha China | 2933990099. Mankhwala ena a heterocyclic okhala ndi ma heteroatomu a nayitrogeni okha.Mtengo wowonjezera wa msonkho: 17.0%.Mtengo wochotsera msonkho: 13.0%.Zowongolera: Palibe.Mtengo wamtundu womwe umakomera kwambiri: 6.5%.General tariff: 20.0% |
| Zolengeza | Dzina mankhwala, pophika okhutira, ntchito hexamethylene kolorayidi, chonde onetsani maonekedwe, 6-caprolactam, chonde onetsani maonekedwe, kusaina tsiku. |
| Chidule | 2933990090. heterocyclic mankhwala okhala ndi nitrogen hetero-atomu (ma) okha.VAT: 17.0%.Mtengo wochotsera msonkho: 13.0%..Mtengo wa MFN: 6.5%.General tariff: 20.0% |
Njira Yopanga
Caspofungin iyenera kukonzedwa ndi ukadaulo wa semi-synthetic fermentation.Zopangira zopanda pake za mphete yayikulu ziyenera kupezedwa kudzera muukadaulo wa nayonso mphamvu, ndiyeno chinthu chapakatikati chimapezeka mwa kupatukana ndi kuyeretsedwa, ndiyeno chinthu chapakatikati chimagwiritsidwa ntchito ngati poyambira kumaliza kuphatikizika kwa unyolo wam'mbali pogwiritsa ntchito ukadaulo wopanga kuti pamapeto pake apeze. chandamale Element.Chifukwa "chofufumitsa theka-synthetic" mankhwala ayenera kudutsa maulalo angapo luso monga nayonso mphamvu, kulekana ndi kuyeretsedwa, kaphatikizidwe, etc., luso njira ndi ndondomeko chizindikiro ulamuliro ndi zovuta mu Chemicalbook.Kuphatikiza apo, zofunikira zoyendetsera kulembetsa kwa caspofungin, chinthu chofufumitsa cha semisynthetic, ndizokwera kwambiri.Zolemba zogwiritsira ntchito ziyenera kuyambika kuchokera ku gwero la fermentation, osati kungophunzira mwadongosolo kulima zovuta, ukadaulo wa fermentation, ndiukadaulo woyeretsa, komanso kufufuza kaphatikizidwe kake.Njira, mikhalidwe, ndi kuwongolera zonyansa pakupanga, chifukwa chomalizacho ndi chosalimba, kusasamala kulikonse kudzachotsa zoyesayesa zonse zam'mbuyomu, ndipo zovuta zaukadaulo ndi mtengo wake sizochepa.
Ndi chifukwa cha zotchinga zaukadaulo komanso malo abwino ampikisano zomwe Hengrui Caspofungin adasungabe malo amtengo wabwino pambuyo pa kutchulidwa kwake.
Chitetezo cha patent chinatha mu 2014
Kugulitsa jekeseni wa terminal caspofungin m'mabungwe azachipatala ku China (gawo: yuan zikwi khumi)
Mpaka pano, mankhwala okhawo a Hengrui Pharmaceuticals, Chia Tai Tianqing, Borui Pharmaceuticals, ndi Haisco ndiwo avomerezedwa kuti atchulidwe.Mankhwala a Huadong?
Kampani yoyambirira yofufuza ya caspofungin acetate ndi Merck, ndipo mndandanda wamakampani 6 akuwunikiridwa ndikuvomerezedwa, omwe ndi Qilu Pharmaceutical, Nanjing Yinxing Pharmaceutical, Sihuan Pharmaceutical, Osaikang Pharmaceutical, Sino-US Huadong Pharmaceutical, ndi Tian Weipharmaceutical Bio.
JIN DUN Medical ali ndiKuyenerera kwa ISO ndikukwaniritsa miyezo ya GMP yopanga, olemba ntchito akatswiri apakhomo ndi akunja opangira mankhwala omwe ali ndi luso lotsogolera R&D yamakampani.
Ubwino wa TECHNOL OGY
● High Pressure Catalytic Hydrogenation .High Pressure Hydrogenolysis Reaction .Kusintha kwa Cryogenic (<-78%C)
●Aromatic Heterocyclic Synthesis
●Kukonzekeranso
● Chiral Resolution
●Heck, Suzuki,Negishi,Sonogashira .Gignard Reaction
Zida
Labu yathu ili ndi zida zosiyanasiyana zoyesera ndi kuyesa, monga: NMR (Bruker 400M), HPLC,chiral-HPLC,LC-MS,LC-MS/MS (API 4000),IR,UV,GC,GC,GC-MS, Chromatography, Microwave Synthesizer, Parallel Synthesizer, Differential Scanning Calorimeter (DSC), Electron microscope ...
Gulu la R&D
Jindun Medical ili ndi gulu la akatswiri a R&D, ndipo amagwiritsa ntchito akatswiri ambiri opangira mankhwala apakhomo ndi akunja kuti aziwongolera R&D, kupangitsa kuti kaphatikizidwe kathu kakhale kolondola komanso kothandiza.
Tathandiza makampani angapo apamwamba apanyumba azachipatala, mongaHansoh, Hengrui ndi HEC Pharm.Apa tikuwonetsa gawo lawo.
Kusintha Mwamakonda Mlandu Woyamba:
Cas No.: 110351-94-5
Mwamakonda Mlandu Wachiwiri:
Cas No.: 144848-24-8
Kusintha Mwamakonda Mlandu Wachitatu:
Cas No.: 200636-54-0
1.Sinthani Mwamakonda Anu Apakati kapena ma API.Monga momwe tafotokozera pamwambapa, makasitomala ali ndi zofuna za Intermediates kapena ma API, ndipo sangapeze zomwe zimafunikira pamsika, ndiye titha kuthandiza Kusintha Mwamakonda Anu.
2.Kukhathamiritsa kwa Zinthu Zakale.Gulu lathu lithandizira Kukulitsa ndi kukonza zopanga zotere zomwe njira yake ndi yakale, mtengo wopangira ndi wokwera, ndipo magwiridwe ake ndi otsika.Titha kupereka zolembedwa zonse za kutengerapo kwaukadaulo ndi kukonza njira, kuthandiza kasitomala kuti apange bwino.
Kuchokera ku zolinga za mankhwala kupita ku INDs, JIN DUN Medical amakupatsiraninjira imodzi yokhayokha ya R&D.
JIN DUN Medical amaumirira kupanga gulu lokhala ndi maloto, kupanga zinthu zolemekezeka, zanzeru, zolimba, ndikupita zonse kuti mukhale bwenzi lodalirika komanso bwenzi lamakasitomala!
