2-butyl-5-nitro-3-benzofuranyl) [4--[3-(dibutylaMino) propoxy]phenyl]

Ndi matenda ntchito pulayimale ndi sekondale Hyperuricemia, makamaka odwala hyperuricemia, komanso odwala aimpso insufficiency, ndi odwala ndi zinabadwa kapena aakulu gout, komanso odwala Hyperuricemia.ntchito odwala Gouty nephropathy kuthetsa zizindikiro ndi kuchepetsa mapangidwe aimpso uric acid miyala;miyala ya gout;amagwiritsidwa ntchito mu uric acid miyala ya impso ndi uric acid matenda a impso.

Mankhwala atsopano oletsa arrhythmic Atrial fibrillation (AF) ndi matenda omwe angathe kupha moyo.Chifukwa cha kukalamba kwa anthu, zochitika zapadziko lonse lapansi komanso kufa kwa fibrillation ya atria zikuchulukirachulukira, ndipo zakhala zovuta zatsopano zapagulu.Ku United States kuli odwala 2.5 miliyoni omwe ali ndi vuto la atrial fibrillation ndi 4.5 miliyoni ku European Union.Malinga ndi ziwerengero, kuchuluka kwa fibrillation yam'mimba mwa anthu opitilira zaka 30 m'dziko langa ndi 0,77%, komwe kumawonjezeka ndi zaka, ndipo amuna ndi apamwamba kuposa akazi (0,9%: 0,7%).Matenda amene amayambitsa kugunda kwa mtima kumaphatikizapo kuthamanga kwambiri kwa magazi, matenda a mtima, matenda a mtima wa valvular, matenda a mtima amene amatuluka mwadzidzidzi, ndiponso kulephera kwa mtima.Waukulu chizindikiro cha odwala matenda fibrillation ndi kusakhazikika yamitsempha yamagazi kugunda, ndi kugunda kwa mtima kulamulira ali ndi udindo wina pachimake mankhwala ndi yokonza zizindikiro.Amiodarone imathandizira kwambiri kuwongolera kugunda kwa mtima ndikubwezeretsanso kugunda kwa sinus, koma zotsatira zoyipa za ziwalo zomwe zimakhudzidwa ndi gawo la ayodini mu kapangidwe kake zimalepheretsa kugwiritsa ntchito kwake kuchipatala, monga kuwonongeka kwa mapapo, chithokomiro, ndi chiwindi.Zomwe tazitchula pamwambapa ndi kapangidwe kake Iodine mkati imagwirizana kwambiri.Mankhwala atsopano a antiarrhythmic Dronedarone (Dronedarone) adapezedwa mwa kusintha kapangidwe ka amiodarone.Dronedarone imakhala ndi electrophysiological properties yofanana ndi amiodarone, koma ilibe ayodini m'mapangidwe ake, kotero imatha kupeŵa zotsatira zoopsa za mtima zomwe zimachitika chifukwa cha ayodini Chemicalbook.Dronedarone inavomerezedwa kuti igulitse malonda ndi US Food and Drug Administration (FDA) mu July 2009, ndipo inavomerezedwa kuti igulitse ku European Union ku 2009. Ndiwo mankhwala oyambirira a antiarrhythmic omwe amavomerezedwa ku European Union m'zaka za 10.Dronedarone ndi N--[2-butyl-3--[4-(3-(dibutylamino)]phenyl]-5-benzofuranyl]-methanesulfonamide, yomwe imachepetsa kutulutsa kwa benzofuran komwe kumapezeka mwa kusintha kwapangidwe kwa amiodarone, komwe sikuli mtima choyipa.Amachotsa atomu ya ayodini mu amiodarone kuti achepetse kawopsedwe ka chithokomiro ndi ziwalo zina;imawonjezera gulu la methylsulfonyl pa mbali ya benzofuran kuti muchepetse lipophilicity, potero kufupikitsa theka la moyo wa mankhwalawo ndikuchepetsa kuchuluka kwa minofu komanso kuthekera kwa mankhwala a neurotoxicity.Zonse za 2011 US version ndi 2010 European version ya Atrial Fibrillation Guidelines imalimbikitsa dronedarone pochiza matenda a atrial fibrillation.Dronedarone ndi yotetezeka komanso yothandiza pochiza chiwopsezo cha ventricular komanso kusunga sinus kwa odwala osiyanasiyana opanda AF yoopsa.Itha kukhala mankhwala othandiza kusintha amiodarone.Dronedarone imathanso kuchepetsa imfa ya odwala AF komanso ngakhale odwala AF omwe amapitilirabe.Chifukwa chake, akuyembekezeka kukhala mankhwala oyamba kwa odwala AF popanda kulephera kwamtima kwakukulu.Kuphatikiza apo, kugwiritsa ntchito anticoagulants kwa odwala omwe ali pachiwopsezo chapakati pa AF ndikopindulitsa kugwiritsa ntchito dronedarone.