3-Amino-4-pyrazole carbosamide hemisulfate

Pakatikati pa kaphatikizidwe ka allopurinol.

Ndi imodzi mwa mndandanda wa 3-amino-4-substituted pyrazole.Ikhoza kugwiritsidwa ntchito ngati yapakatikati kuti ipangitse mankhwala ambiri a pharmacologically ogwira ntchito, monga allopurinol, imodzi mwa mndandanda wa pyrazolopyrimidine, wotsirizira kuyambira 1963 Chiyambire kugwiritsidwa ntchito kwachipatala, wakhala mankhwala akuluakulu ochizira gout.Pakalipano, pali njira zochepa zodziwika zopangira synthesizing

3-aminopyrazole-4-carboxamide hemisulfate ku China, makamaka pochita malononitrile ndi triethyl orthoformate kukonzekera ethoxymethylene malononitrile, ndiyeno ndi Zomwe hydrazine hydrate zimatulutsa 3-amino-4-cyanopyrazole, zomwe pamapeto pake zimakhudzidwa ndi asidi wambiri kuti apange sulfuric acid.

3-aminopyrazole-4-carboxamide hemisulfate (Chen Huiru, Xiao Guomin et al. 3-aminopyrazole- Synthesis of 4-formamide hemisulfate [J]. Chemical Industry Times, 2008, 6 (22): 39 40), zokolola zonse za kaphatikizidwe ndi njirayi ndi pafupifupi 60% (yowerengedwa ngati malononitrile), njira iyi Imaphatikizapo kuchitapo kanthu katatu, masitepewo amakhala otalika, ndipo ma reagents omwe amagwiritsidwa ntchito, monga malononitrile ndi ethoxymethylene malononitrile, ndi owopsa komanso okwera mtengo.Kuonjezera apo, 3-aminopyrazole-4 yokonzedwa ndi njira iyi - Formamide hemisulfate ili ndi mtundu umene ndi wovuta kuchotsa ndipo umafunika kukonza zina, zomwe zimakhala zovuta kwambiri.

Pali malipoti m'mabuku akunja omwe amagwiritsa ntchito pyridylamide hydrazone ndi ethoxymethylene malononitrile monga zopangira kuti apeze 3-amino-4-cyanopyrazole powonjezera ndi cyclization, ndiyeno amachitapo kanthu ndi sulfuric acid yokhazikika kuti apeze cholinga (Reuken G Jones. Zochita za orthoesters ndi activemethylene mankhwala [J] J Am Chem Soc. 1952,74 (5): 4889 4891).Zida zazikulu zomwe zimagwiritsidwa ntchito munjira iyi ndizokwera mtengo, zokolola zomwe zimachita sizokwera, ndipo phindu la kupanga mafakitale ndilotsika.Ziyenera kukhala zovuta.